这篇综述是香豆素衍生物合成中使用的绿色合成方法的汇编。香豆素是一类具有显着广泛的生物活性的化合物，已发现它们在医学，药理学，化妆品和食品工业中的应用。它们的生物学活性和潜在应用高度依赖于其结构。因此，许多研究人员每天都在进行香豆素衍生物的合成。对它们的合成的高要求常常导致增加不同化学废料的产生。为了最小化有毒有机物的利用和产生，以这种方式应用了绿色合成方法。在过去的几十年中，这些方法越来越受到关注。绿色化学方法涵盖了多种方法，包括超声波和微波，离子液体和深共熔溶剂的应用，无溶剂合成，机械合成和多组分反应。使用这些绿色合成方法已成功进行了香豆素合成的所有典型缩合反应，如Knoevenagel，Perkin，Kostanecki-Robinson，Pechmann和Reformansky反应。根据该评论中提到的作者，与常规方法相比，这些方法不仅减少了有毒化学物质的利用和产生，而且还提高了产品收率，纯度，能耗和合成后程序的反应性能。方法。由于香豆素作为具有生物活性的系统的重要性以及最近减少有毒溶剂，催化剂和能源消耗的要求，这篇综述提供了关于绿色合成方法在香豆素合成中的应用的第一篇完整的文献综述。它涵盖了1995-2019年期间的文献搜索。这项工作的重要性是针对特定类别的杂环化合物进行全面的文献调查，从事香豆素合成的研究人员可以找到有关绿色合成方法的非常有用的信息。关于香豆素合成有一些评论，但其中大多数仅涉及香豆素合成的特定反应，而没有涵盖绿色化学方法的全部范围。这项工作的重要性是针对特定类别的杂环化合物进行全面的文献调查，从事香豆素合成的研究人员可以找到有关绿色合成方法的非常有用的信息。关于香豆素合成有一些评论，但其中大多数仅涉及香豆素合成的特定反应，而没有涵盖绿色化学方法的全部范围。这项工作的重要性是针对特定类别的杂环化合物进行全面的文献调查，从事香豆素合成的研究人员可以找到有关绿色合成方法的非常有用的信息。关于香豆素合成有一些评论，但其中大多数仅涉及香豆素合成的特定反应，而没有涵盖绿色化学方法的全部范围。

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This review is a compilation of the green synthetic methods used in the synthesis of coumarin derivatives. Coumarins are a class of compounds with a pronounced wide range of biological activities, which have found their application in medicine, pharmacology, cosmetics and food industry. Their biological activity and potential application are highly dependent on their structure. Therefore, many researchers have been performing the synthesis of coumarin derivatives on a daily basis. High demands for their synthesis often result in an increased generation of different waste chemicals. In order to minimize the utilization and generation of toxic organic substances, green synthetic methods are applied in this manner. These methods are getting more attention in the last few decades. Green chemistry methods cover a wide range of methods, including the application of ultrasound and microwaves, ionic liquids and deep eutectic solvents, solvent-free synthesis, mechanosynthesis and multicomponent reactions. All typical condensation reactions for coumarin synthesis like Knoevenagel, Perkin, Kostanecki-Robinson, Pechmann and Reformansky reactions, have been successfully performed using these green synthetic methods. According to the authors mentioned in this review, not only these methods reduce the utilization and generation of toxic chemicals, but they can also enhance the reaction performance in terms of product yields, purity, energy consumption and post-synthetic procedures when compared to the conventional methods. Due to the significance of coumarins as biologically active systems and the recent demands of reducing toxic solvents, catalysts and energy consumption, this review provides a first full literature overview on the application of green synthetic methods in the coumarin synthesis. It covers a literature search over the period from 1995-2019. The importance of this work is its comprehensive literature survey on a specific class of heterocyclic compounds, and those researchers working on the coumarin synthesis can find very useful information on the green synthetic approaches to their synthesis. There are some reviews on the coumarin synthesis, but most of them cover only specific reactions on coumarin synthesis and none of them the whole range of green chemistry methods.